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“World-class aseptic liquid filling platform”

Bosch and GSK have developed a pioneering aseptic filling line with robot technology, which is presented for the first time at Achema 2018.

GlaxoSmithKline (GSK) is well-known as an innovator in pharmaceutical products and processes. Inspired by the advancement of robotics in many other industries, GSK challenges the traditional aseptic model and aspires the total removal of the operator from the aseptic filling and stoppering process and to prevent environmental monitoring (EM) intrusions.

According to Nigel Wood, Engineering Capital Director, Manufacturing at GSK, the company found an ideal partner to set out on this innovative journey. “We chose Bosch based on past collaboration and the ability to deliver new technology platforms on time to budget, while meeting the highest quality standards for aseptic processing.”

A future-proof concept

The new line is designed for vials and syringes. Robots are used to minimize manual glove port manipulations including EM, and to reduce both the amount and the complexity of equipment. They offer full flexibility regarding packaging types with rapid format change, also to ensure accurate and clean container handling. Above all, the concept is future-proof and can be further adapted to meet GSK’s aspirations.

“Our goal was to develop a world-class aseptic liquid filling platform for biopharmaceuticals,” Nigel Wood explains. “Apart from robot technology, highest pharmaceutical quality is especially important for this line, which will deliver our new pipeline of biopharmaceutical liquid products.” This includes the use of isolator technology for sterility assurance, automatic double bag opening for RTU containers with final bag opening in the grade A isolator. The platform includes 100% in-process control to ensure highest possible yield and filling accuracy.

Visitors to Achema can get a first impression of the new line and the long-term vision of the partners via multimedia presentations in hall 3.1, at booth C71.

 

Contact:
Klaus Ullherr
Senior Product Manager
+49 (0)7951 402 517
klaus.ullherr@bosch.com

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